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Side effects with NAC supplements include gastrointestinal symptoms, which occur in up to 23% of patients.[ref] While generally safe at supplemental doses, a drawback to N-acetyl cysteine is the sulfur smell and taste

According to human and animal studies, metformin may reduce visceral fat by boosting the oxidation (breakdown) of liver fat and increasing thermogenesis, the bodys way of burning calories to produce heat

3.3 Gut microbiota participates in bile acid metabolism Gut microbiota dysbiosis is a key factor in abnormal bile acid (BA) metabolism and obesity

This matters most for tendons, ligaments, and cartilage, which have limited blood supply and dont respond well to standard anti-inflammatory approaches