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It is anticipated that studies of the immunogenicity of naturally eluted hapten-modified peptides will help determine whether modification of specific source proteins impacts the development and severity of tissue injury and tissue selectivity of an adverse event

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Subsequently, further stratification by folate status in the case of the MTHFR models or by cobalamin status in the case of the MTRR models was performed to investigate whether low or normalhigh folate or cobalamin status affects the association between the polymorphisms and tHcy