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(2) Cross-nutrient common mechanistic gaps and future research directions Across all nutrient categories, three critical gaps in mechanistic understanding persist and must be addressed in future research: Quantification of microbiota-metabolite-depression thresholds: for example, the minimum amount of dietary fiber required to elevate fecal butyrate concentrations to levels that alleviate depressive symptoms remains unclear

Covalent binding to GSH reduced the levels of GSH, thereby shifting the intracellular balance of ROS generation/antioxidant responses toward ROS generation

doi: 10.3389/fpubh.2022.947051 Summary Keywords haem acquisition, new therapeutic agents, nontypeable H

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