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Esta accin tiene un impacto sistmico, ya que al prevenir el paso de macromolculas al torrente sanguneo, reduce la inflamacin sistmica de bajo grado , a menudo manifestada como dolor articular y niebla mental

In addition to the drugs that ameliorate inflammation in GA by targeting TLRs, sparsolonin B inhibited FA-induced macrophage inflammation in an osteoarthritis model by selectively blocking the TLR4/MD-2/NF-B axis (177)