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Barroeta I, Videla L, Carmona-Iragui M et al (2025) Current advances and unmet needs in Alzheimers disease trials for individuals with Down syndrome: navigating new therapeutic frontiers

Minimal impact beyond melatonin restoration

Although senolytics exhibit cell type specificity in targeting senescent cells, their clinical translation remains limited by the absence of standardized biomarkers or universally accepted diagnostic criteria to guide precision interventions

Those interactions continue driving fibroblast activation, angiogenesis signaling, and metalloproteinase modulation long after the peptide has been metabolized and excreted