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In humans, GPx4 exists in three alternatively spliced isoforms: cytosolic GPx4 (cGPx4), mitochondrial GPx4 (mGPx4) and sperm nucleus GPx4 (snGPx4) [1, 8]

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3.7 Effect of glutathione administration on endothelium-dependent relaxation of isolated vascular rings Figure 5A shows typical records of relaxation curves of vascular preparations due to different doses of acetylcholine application against the background of norepinephrine-induced vasoconstriction of glutathione-treated and untreated old rats