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At the molecular level, the mechanism has been structurally resolved by NMR spectroscopy (Nature Communications, 2025): FOXO4-DRI binds to the disordered p53 TAD2 domain and forms a transiently folded complex through both the FOXO4-derived peptide region and its cationic cell permeability element

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(Source 2, 3) Some scientists and clinicians, especially in functional and longevity medicine, propose increasing glutathione levels, primarily through supplementation, to promote health and prevent disease with aging