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Most lyophilized peptides are stable for months at minus 20 degrees Celsius but degrade meaningfully at room temperature over days to weeks through oxidation, hydrolysis, and aggregation

So even the topical route, which is the evidence-backed one, should be described as supported by small, sometimes industry-affiliated human cosmetic studies with modest effect sizes, not as proven. The correct posture toward topical GHK-Cu is cautious optimism grounded in real but imperfect human data which is still a materially stronger position than the injectable route can claim