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This complex consists of core subunits ( Paf1 , Leo1 , Cdc73 , Rtf1 , and Ctr9 ) and a unique subunit specific to humans ( Ski8 )

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Alterations in external conditionssuch as dietary factors, chemical exposures, and psychological stressorsor cellular stress can induce changes in epigenetic marks, leading to gene transcription activation or silencing