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Additionally, mechanical injuries, such as joint wear, trigger inflammatory responses in cartilage and synovium, further upregulating the expression of matrix-degrading proteins, accelerating ECM degradation, and promoting OA progression (Maldonado and Nam, 2013)

Thus, we performed phasor fluorescence lifetime imaging (phasor-FLIM) to measure fluorescence lifetime ( f ), which can be correlated to the molecular self-assembly 21,34

10.1016/j.jchromb.2004.07.021 J