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As can be seen in Figure 6D, yeast transformed with plasmid-encoded gliT were capable of growth in the presence of gliotoxin (16 and 64 g/ml, respectively) depending on whether minimal or rich media was used to support growth, while those transformed with empty vector were unable to grow, irrespective of what media conditions were used

In addition to generalized neurotrophic deficits, impaired adult hippocampal neurogenesis has emerged as a central and independent pathophysiological mechanism in depressive disorders (41)

We would like to understand how oxidative stress (and the chromosome 21 trisomy in the case of Down syndrome) could create these disturbed profiles

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