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Misdiagnoses, and the variability in symptom severity within ME/CFS cohorts, likely influences study outcomes aimed at identification of disease-associated biomarkers (Xu et al., 2023)

Simon G, Subbiah V, Rosen L, Lenz H-J, Park H, Patel M, et al

Food Funct 14(17):77997824 Tsao JP et al (2025) Effect of astaxanthin supplementation on cycling performance, muscle damage biomarkers and oxidative stress in young adults: a randomized controlled trial

While we recognize the concerns expressed by the requestor for this subset of patients with respect to the younger population and the lower volume of cases, we note that the logic for case assignment to MS-DRGs 432, 433, and 434 includes clinically related diagnoses that differ in severity and resource intensity with alcoholic hepatitis being at the lowest end of the severity spectrum