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A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome

doi: 10.1146/annurev.immunol.22.012703.104635 21 OGarraA.BrittonW

Release of presynaptic glutamate and activation of postsynaptic glutamate receptors on the postsynaptic neuron stimulate influx of Na + and Ca 2+ ions into the postsynaptic neuron, which contributes to depolarization and action potentials ( Glutamate Transporters and Receptors Excitatory Amino Acid Transporters Increased levels of extracellular glutamate, particularly asynchronistic glutamate levels, cause cellular damage when excitatory neurotransmission is sufficiently aberrant (Pitt et al., 2000

Others, like glutathione, also have limited bioavailability in oral form because it can be easily degraded during digestion