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doi: 10.1002/mas.20060

For example, ROS-responsive nanoparticles self-assembled from a hybrid platinum prodrug CPT-Pt (IV), ROS-sensitive polymer, and mPEG2k-DSPE can accumulate at tumor sites and release cisplatin and CPT, leading to DNA double-strand damage, ultimately activating the cGAS-STING pathway, inducing DCs maturation and increasing tumor infiltration of CD8 + T cells (230)

Livanos AE, Jha D, Cossarini F, Gonzalez-Reiche AS, Tokuyama M, Aydillo T, et al

The incidence and severity of high-altitude disease are determined by the attained altitude, ascent variables (including environmental and behavioral factors), and individual susceptibility