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Recently, a human gene mutation of PAPP-A2, a circulating and tissue protease with IGFBP-5 (and to some extent IGFBP-3) as its primary substrate (Gaudamauskes et al), was demonstrated to have a marked growth phenotype involving fetal and post-natal growth retardation in children in a consanguineous family (43)

Spider-venom peptides that target the human NaV1.7 channel: Potential analgesics for the treatment of chronic pain

49 , e12917 (2023)