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This can result in symptoms such as brain fog and sensitivity to supplements and chemicals

Further studies could explore these unknowns signaling pathways to understand the mechanism of action of metformin in glioma treatment more comprehensively

Mechanisms are still unclear researchers still cant pinpoint DSIPs receptor or exact biological pathway

Finally, with respect to the initial cytoprotection theory, which includes epithelium and endothelium (cyto)protection and should be further expanded to protection of other organs (Kang et al., 2018