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K., Holma, R

Its signature research property is telomerase activation and potential extension of telomere length in certain cell types

In contrast, SCs isolated from muscle-specific IGF-1 transgenic mice showed enhanced proliferative capacity in vitro, and the effect was mediated by activation of PI3K/Akt, independent of MAPK, and downregulation of the cyclin-dependent kinase inhibitor p27 Kip1 , supporting the role of IGF-1 in regulation of the cell cycle in SCs [122]