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Defined stereochemistry is critical in structural verification workflows, as stereoisomers may display distinct spectroscopic and chromatographic behaviour

lifestyle changes are important but alone are insufficient to prevent future gout flares from occurring Titrate urate-lowering medicine doses until the patient achieves a serum urate level below 0.36 mmol/L

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A water thermo-regulator was used to maintain constant temperature (37 0.5 C) for the whole Langendorff system, KH buffer was filtered (0.45m) and gassed with 95% O 2 / 5% CO 2 to obtain a pO 2 600 mmHg and a pH = 7.4