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In some embodiments, the otic formulation or composition comprises about 2% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

The dose of 150 nmol/kg sCT was chosen to compare the effect of sCT and cagrilintide in vivo as this dose of sCT shows the same pharmacokinetic response as the 3 nmol/kg of cagrilintide

Leu244 at the 2 nd activity controller position of jr PPO1-wt was mutated to a positively charged arginine (Leu244Arg), leading to a decrease of the k cat values for mono- and diphenolic substrates by 15-fold for tyramine, 4-fold for dopamine and 11-fold for L -DOPA in comparison to jr PPO1-wt (Table 2)

TC and PC conceptualized the review and revised it together with AB, FM, and DV