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The clinical drug development program was halted in 2007 after the pivotal Phase IIb trial did not show statistically significant weight loss in the primary endpoint

While originally studied for gastrointestinal healing, research has expanded to investigate its potential effects on musculoskeletal tissues, making it a subject of interest in veterinary medicine, particularly for canine orthopedic conditions

Water retention Some puffiness or bloating, especially in hands and face, as IGF-1 causes cells to hold more water

Sermorelin, also a GHRH analog, was once FDA-approved for pediatric GH deficiency but is no longer marketed