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Functionally, cagrilintide activates amylin receptors AMY1R, AMY2R, AMY3R and the calcitonin receptor (CTR), binding via a conserved bypass motif involving mid-segment residues (S19 P25) (Cao et al

In the context of autoimmunity, the most relevant are those that influence T-cell differentiation, cytokine production, inflammatory signaling pathways, and immune cell communication