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Age-related changes in body composition and their sequelae Progressive change in body composition occurs with ageing, characterised by four phenotypes in older adults, that can increase the likelihood of mortality through comorbid disease [11]: sarcopenia, healthy weight, obesity and sarcopenic obesity [12] (Fig

p163MR mice and the peptide FOXO4-DRI are subject to patent applications and may be shared with research organizations for research and educational purposes only under an MTA to be discussed in good faith with the recipient

The peptide's unique molecular mechanisms involving angiogenesis pathway activation, growth hormone receptor upregulation, and anti-inflammatory modulation distinguish it from conventional therapeutic approaches and provide biological rationale for its observed effects in experimental models