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How TNF- changes in peritoneal fluid tie in with endometriosis phenotypes and menstrual phases was unclear, with reported increases in both stages I/II and III/IV [32], only in stage III/IV with no difference between proliferative and secretory phases, or only in patients with endometrioma and in proliferative phase [135] some of which may reflect inappropriate statistical power to control for Type II errors when stratifying cohorts

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To show that the sphincters failure is a part of the NSAIDs-toxicity, COX-1 and COX-2 inhibitors were used in dose regimens shown to induce gastric and small intestine ulcers, hepatotoxicity and encephalopathy (8-14)