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However, asynchrony between oocytes and spermatozoa, especially when aged oocytes are fertilized, will affect the rates of fertilization and embryo development, thus reliable methods are needed to control oocyte aging to benefit modern ART [28]

OPG deficiency increases the number of M cells in gut-associated lymphoid tissue (GALT), enhances antibody responses to commensal bacteria, alleviates IBD, and reduces inflammation-induced abnormalities in bone metabolism (235)

Local sources include: Brown rice Sunflower seeds Whole wheat roti Tuna or sardines (available in coastal cities like Karachi) Balanced plate idea: Mix daal, brown rice, and a salad with lemon juice for a full antioxidant meal

They monitored IGF-1 levels, tracked insulin sensitivity, and conducted oral glucose tolerance tests