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Two group comparisons were throughout performed using Students two-tailed unpaired t test

The conversion of ribonucleotides to deoxyribonucleotides, through the action of ribonucleotide reductase, requires NADPH, therefore any rapidly proliferating cell needs large quantities of NADPH

Disruption of this balance may exacerbate the condition

28 Hair graying emerges from an intricate interplay of biological factors that vary among individuals, primarily driven by the accumulation of oxidative and DNA damage, hyperactive mTORC1 signaling, premature melanocyte aging, and insufficient production of pigmentation-promoting factors within the hair matrix