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Digestive discomfort: Some people experience mild stomach upset, bloating, or cramps, especially when taking large doses at once

Nivolumab for recurrent squamous-cell carcinoma of the head and neck

Abu-Hayyeh, S

[2] The reasoning behind the local designation was structural as much as functional: because the E-domain reading-frame shift alters the C-terminal sequence, the variant was predicted to interact differently with the binding proteins present in muscle interstitial spaces, keeping its action localized and its half-life short