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Consequently, the direction of LPA-LPAR signaling is primarily determined by the specific G protein subtypes coupled to the involved LPARs, which in turn drive downstream signaling cascades and ultimately regulate various cellular biological behaviors, including proliferation, survival, inflammatory responses, immune responses, migration, and differentiation

A.AgarwalV.HunkelerA.OrgM.-L.SamosonA.et al (2015)

Research Insight Helps researchers explore biological repair pathways and protective activity in cells

This fast clearance reflects the dominant degradation mechanism: N-terminal cleavage of tryptophan by plasma and CSF aminopeptidases