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however, this enzyme was mutated in hominoids five to fifteen million years ago.[1] This loss of uricase activity not only results in higher plasma UA levels, but also limits our ability to regulate UA, such that widely varied levels may be observed in man

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The OS parameters evaluated in this study include malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GSH-Px), and protein content that were measured as per the methods described by Ohkawa et al

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