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However, their proteome-wide impact on small-molecule recognitionand, thus, druggabilityremains largely unexplored

Studies have also shown that ALA is able to generate ROS, which promote ALA-dependent cell death in lung cancer [75], breast cancer [76] and colon cancer [77,78], suggesting that it triggers the mitochondrial pathway of apoptosis in cancer cells

Ramos H, Bogdanov P, Sampedro J, Huerta J, Sim R, Hernndez C (2020) Beneficial effects of glucagon-like peptide-1 (GLP-1) in diabetes-induced retinal abnormalities: involvement of oxidative stress

While effective when taken as directed, clonidine requires careful dosing because too much can quickly lead to serious health problems