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If there is disruption of the tight junction proteins, then these larger molecules can pass through the leak pathway, and the ratio in urine or blood between lactulose and mannitol or L-rhamnose, is used to represent permeability

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doi: 10.1159/000488326 Summary Keywords Sucrosomial vitamin B12, Sucrosomial technology, vitamin B12 deficiency, oral B12 supplement, vitamin B12 bioavailability Citation Memon NM, Conti G, Brilli E, Tarantino G, Chaudhry MNA, Baloch A, Shafiq A, Mumtaz SU, Qaisar W, Iqtadar S, Abrar S, Kanwal A, Akhtar MH, Latif H, Rabbani F, Ujjan ID, Turroni S and Khan A (2024) Comparative bioavailability study of supplemental oral Sucrosomial vs

doi: 10.1016/j.cherd.2024.04.048