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Molecular docking confirmed the kinetic data, suggesting that the - -stacking system as well as non-covalent interactions between the 1 st and 2 nd activity controller and the tail of substrates are responsible for substrate stabilization and correct orientation

Culturing was performed in RPMI 1640 medium enriched with 10% fetal bovine serum, maintained at 37C in a humidified incubator with an atmosphere of 5% CO 2 and 95% air