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Comprehensive biochemical testing demonstrates that 5 amino 1mq does not inhibit structurally similar methyltransferases, including catechol-O-methyltransferase (COMT), DNA methyltransferase 1 (DNMT1), or protein arginine methyltransferase 3 (PRMT3)

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Some studies have reported an association between 5ARI usage and depressive symptoms, though a definitive causal relationship has not been established [61]

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