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IAP dephosphorylates LPS and prevents it from binding TLR4, thus inhibiting NF-B pathway activation, ultimately reducing proinflammatory cytokine release (50)

10.1016/j.bbr.2018.11.047 Behav

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The largest trial involving DSIP to date, which included a total of 107 volunteers, reported that the peptide was generally well-tolerated with mostly minor side effects, which included [8]: Low blood pressure Increased sweating Headache Nausea Vertigo Considering that the drop in blood pressure was reported as moderate to severe in some patients, researchers should consider hypotension as a potentially exclusionary criterion for DSIP research