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Description

Although 6-phosphoglucono--lactone is hydrolytically unstable and can undergo spontaneous (nonenzymatic) ring-opening at a significant rate, this hydrolysis reaction is greatly accelerated in the cell by the enzyme 6-phosphogluconolactonase (EC 3.1.1.31)

Genes Dev 15 , 30593087 (2001)

However, higher levels of intake of alpha-tocopherol (like achieved by taking supplements) are associated with decreased blood coagulation

No mechanism has been identified by which GHK-Cu would blunt metformin's glucose-lowering effect or by which metformin would impair GHK-Cu's tissue repair signaling