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It also interacts with melanocortin receptors, particularly MC1R, which are expressed on immune cells including macrophages, dendritic cells, and T cells

Continue treatment for 48 hours after the eye appears normal, but do not use it for longer than 5 days unless advised by a doctor

As such, it appears that COVID-19 (and other viral infectious diseases) is accompanied by three different inflammatory phases: (a) beneficial protective inflammation, which combats the infection and may mount a restorative repair, (b) hyperinflammation, which may lead to a cytokine storm and critical disease or even death, and (c) non-resolving inflammation resulting in a protracted mild inflammatory state [105] as observed in Long COVID

(1981) confirmed significant acute and delayed effects on human sleep behavior