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But we needed to make sure that it was working in actual lifelike settings. The high degree of gluten degradation observed in the trial suggests that TAK-062 can effectively detoxify the couple hundred milligrams of gluten that are often inadvertently ingested by people striving for a gluten-free diet, according to Dan Leffler, a gastroenterologist and medical director at Takeda

Requires vitamin C cofactor (ascorbic acid) for proper crosslinking

Grano and De Tullio therefore proposed that organisms that have lost vitamin C biosynthesis have an advantage: they can finely regulate HIF1 activation on the basis of the dietary intake of vitamin C (Grano & De Tullio 2007)