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VKR in vitro activity assay Enzymatic activity of FSP1 converting K vitamins to their hydroquinone forms was evaluated directly by measuring different forms of vitamin K as the substrate using a conventional reversed-phase HPLC assay 69

46 Liver disease In a 72-week phase 2 study of patients (n = 320) with metabolic dysfunction-associated steatohepatitis (MASH), semaglutide (0.1, 0.2 or 0.4 mg daily) reduced steatosis but had no effect on fibrosis