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Lipid peroxides and their metabolites, such as malondialdehyde (MDA) and 4-hydroxynonenal, damage proteins, membrane integrity, and DNA structure, leading to cell membrane hyperpermeability and ferroptosis (Lei et al., 2022)

This is the most common route for B12 in a clinic, usually into the deltoid muscle of the upper arm

The first step is mediated by -glutamylcysteine synthetase (GCLC), which catalyzes the -amide bond between the -carboxyl group of glutamate and the amino group of cysteine to form -glutamyl-cysteine (-Glu-Cys)

The principal research objective of this multicenter double-blinded randomized placebo controlled trial was to determine the dose required to achieve physiological melatonin blood levels in preterm infants, similar to that of the mother and to define its pharmacokinetic profile in preterm infants