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223 However, clinical studies have shown that not all obese individuals exhibit OA progression, and high OA prevalence is also observed in non-weight-bearing joints such as the hands and shoulders

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A composition, comprising: at least one hepatocyte growth factor (HGF) mimic having the general formula: where R 1 is an amino acid selected from tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, histidine, glycine, cysteine, methionine, tryptophan, lysine, norvaline, ornithine, and s-benzyl cysteine

Ranjani et al., 2019)