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At the vascular and interstitial level, pathological angiogenesis and altered fluid dynamics restrict the entry of blood-borne carriers into the tumor and make their distribution within the tissue highly uneven [31,32,33]

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We also demonstrated that the permeability of GSH-targeted nanoparticles was increased across the cARLA-improved human BBB co-culture model [40] improving the predictive value of the current model for BBB penetration