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However, GdCl 3 permanently destroys KCs by blocking K-type calcium channels (Paasz and Czekaj, 2000), thus unsuitable for clinical use

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Though IL-17A is typically thought of as a pro-inflammatory factor, its absence actually exacerbates intestinal inflammation in CD and compromises the barrier function of intestinal epithelial cells, whereas inhibiting IL-23 secretion significantly reduces inflammatory responses (183185)

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