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Transl Psychiatry

The key finding was that 75% of weight lost was fat and 25% was lean tissue, a ratio that confirms tirzepatide is not simply causing indiscriminate weight loss but preferentially targeting visceral and subcutaneous fat

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In a recent EWAS study, 792 genes were hypermethylated and 2341 were hypomethylated in children with overweight/obesity as compared to those with normal weight, with the genes PCDHGA4, BRD2 and PTPRN2 involved in regulating dysglycemia and the hypothalamic appetite network, obesity and type 1 diabetes having the highest number of differentially methylated sites [158,159,160] Another study comparing obese vs