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As a triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously, retatrutide activates three metabolic pathways where semaglutide activates one and tirzepatide activates two

A sulfur-containing compound

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Additionally, we identified insulin-like growth factor 1 receptor (IGF1R), AKT serine/threonine kinase 1 (AKT1), prostaglandin-endoperoxide synthase 2 (PTGS2), estrogen receptor alpha (ESR1), and epidermal growth factor receptor (EGFR) as potential targets, luteolin has an ideal affinity for these targets, suggesting that it may play a positive role in depression through multiple targets, mechanisms, and pathways