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Significant positive correlations were observed between eryptosis level and all analyzed peritoneal biomarkers of peritonitis, highlighting a potential link between systemic effect (eryptosis) and local inflammation (peritoneum in PD-related peritonitis patients), and definitely confirmed that eryptosis is mostly influenced by blood composition [271]

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Several studies have optimized urea-containing compounds such as SBI-797812 and 1-(2-phenyl-1,3-benzoxazol-6-yl)-3-(pyridin-4-methyl)urea (DS68702229) as potent NAMPT activators, which have been shown to increase NAD + levels in vitro and in vivo, with potential applications in treating metabolic disorders, cardiovascular diseases, and neurodegeneration preclinically 221,222