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Furthermore, Pt-induced ROS production can also promote the secretion of proinflammatory cytokines, for example, TNF-, interleukin-1 (IL-1), interleukin-6 (IL-6), chemokine ligand 2 (CCL2), and so on ( Overall, the accumulation of Pt drugs in the DRG intensifies DNA damage and ROS production

A While this shows the effectiveness of carbon filtration, it should be noted that in the U.S., adding fluoride to community water supplies of many cities has improved the oral health of millions of American citizens

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