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In contrast, melatonin levels were reduced in the tissues examined, particularly so in the brain

It also induces vasorelaxation through both endothelium-dependent (activation of the NO/cGMP pathway) and independent mechanisms (inhibition of Ca 2+ influx into VSMCs, likely through the blocking of voltage-gated CCs (VGCCs)) (310)

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Finally, because of the varied locations and antioxidant capacities of different antioxidants, it is clear that consumption of a single antioxidant in the diet (e.g., vitamin C) is not sufficient to provide optimal protection from radical-mediated damage in cells