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In combination, the temporary rise in intracellular calcium and the activation of PKC may activate the genes associated with growth hormone synthesis and also stimulate the release of growth hormone molecules out of the pituitary cells

This index was significantly lower, not exceeding 30%, in the case of monotherapy, except for the OV1946 cell line, where the percentage was approximately 60% for ABT-263 and about 50% for olaparib [137]

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Finally, we highlight that the interplay between trained immunity and inflammatory diseases remains incompletely understood, and further research is needed to elucidate its mechanisms and clinical translational potential