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N-Acetylcysteinea safe antidote for cysteine/glutathione deficiency

At present, there are four kinds of western medicines used clinically to treat RA: nonsteroidal anti-inflammatory drugs, glucocorticoids, anti-rheumatic drugs and biological agents

Results Neuronal GCLC knockout leads to brain atrophy accompanied by neuronal cell death To examine how the declines in GCLC and glutathione might affect brain homeostasis, we prepared GCLC floxed X CaMKII-Cre (GCLC-KO) mice whose GCLC expression is deleted in calcium/calmodulin-dependent protein kinase II (CaMKII)-positive neurons