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Concerns about potential safety and efficacy issues have turned the peptide into a kind of gray-market celebrity, where consumer safety and efficacy are almost certainly a risk

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For patients without absorption disorders, high-dose oral supplements of 1,000 to 2,000 mcg daily have been shown to be comparably effective at correcting mild to moderate deficiency at lower cost and greater convenience.

The symptoms of spinal stenosis include: Back pain that may feel burning, aching, or radiate into the extremities Back pain that worsens when you walk or stand, particularly for long periods Numbness, cramping, and tingling in the lower extremities A heavy sensation in the legs and foot drop, the term used for the foot slapping onto the ground when you try to walk Loss of balance or coordination Typically, these symptoms worsen gradually over time, becoming disruptive to daily activities in the later stages