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Phase I dose-escalation clinical trial, revealed that PT2385 was well tolerated, with no dose-limiting toxicities

Thus, MASLD patients contrast to patients that have progressed to liver cirrhosis, as these patients are more susceptible to developing sarcopenia, a chronic catabolic state with increased energy expenditure, decreased appetite, low protein synthesis, and the development of ascites or portosystemic shunts that contribute to muscle atrophy (130)

Osteoarthritis burden and inequality from 1990 to 2021: a systematic analysis for the global burden of disease Study 2021

Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells